17beta hydroxysteroid dehydrogenase 3 deficiency

When looking at Glabridin (one of the main bioactives in Licorice supplements without Glycyrrhizin or its derivatives), Gliabrin also appears to inhibit P-Glycoprotein weakly [73] and inhibited the P450 enzymes of CYP2B6, CYP2C9, and CYP3A4. [74] When licorice extract is incubated with CYP3A4, activity was reduced at concentrations of , , 14, and 69ug/mL to 73%, 45%, 25%, and 12% of control levels after 15 minutes and was completely inhibited with 50uM of pure Glabridin and was not reversible. [74] With CYP2B6 inhibition was weaker but followed a similar irreversible trend, and it appeared Glabridin destroyed the heme fragment of these P450 enzymes and thought to be due to its anti-oxidant abilities (as the derivative 2,4-Dimethylglabridin, with no anti-oxidant capabilities, failed to inhibit CYP3A4). [74] Inhibition of CYP2C9 appeared to be reversible and weaker (50% inhibition at 100uM), CYP2D6 was weakly inhibited (15% at 100uM), and CYP2E1 was unaffected. [74]

17beta hydroxysteroid dehydrogenase 3 deficiency

17beta hydroxysteroid dehydrogenase 3 deficiency

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