Individuals who engage in tasks in which they perceive a consistent and high degree of present and anticipated novel and positive outcomes or ‘meaning’ (. sporting events, creative activity, doing productive work) commonly report a feeling of high alertness and arousal that may be construed to be due to the activation of mid-brain dopamine systems. However, a significant subset of these individuals also report a feeling of pleasure that is characteristic of opioid release, but these reports occur only in non-stressed situations when the musculature is relaxed. Since relaxation engages opioid systems in the brain, and because opioid and dopamine systems stimulate each other, the resulting blissful states or ‘flow’ like states require the simultaneous engagement of resting protocols and meaningful cognitive states, behaviors that are very easily achieved. In this way, which engages both resting protocols and an active sense of meaning, both dopamine and opioid release can be increased in the brain, and provide a level of blissful engagement with life’s challenges, or ‘flow’ that can effectively mitigate stress and anxiety.
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