May 12, 2017—The Florida Department of Health Immunization Section would like to share the Human Papillomavirus (HPV) Vaccination Roundtable’s educational live webinar, You've Got the Power to Prevent Cancer . The National HPV Vaccination Roundtable, established by the American Cancer Society (ACS) and the Centers for Disease Control and Prevention (CDC) in 2014, is a national coalition of public organizations, private organizations, voluntary organizations, and invited individuals dedicated to reducing the incidence of and mortality from HPV-associated cancer in the ., through coordinated leadership and strategic planning.
Steroidal glycoalkaloids are a class of glycosidic compounds derived from nitrogen-containing steroids. Structurally it consists of C27 cholestane skeleton to which 1 to 5 sugar moiety is attached at the 3-OH region of the aglycone. The monosaccharides comprise D-glucose, D-galactose, D-xylose and L-rhamnose and many others. Since, nitrogen is inserted into a non–amino acid; these molecules belong to a subclass of pseudo-alkaloids-isoprenoid alkaloids. The structural diversity of glycoalkaloids is confined to two major groups that are based on their aglycone skeleton. The spirosolan category is made up of tetrahydrofuran and piperidine spiro-linked bicyclic system with an oxa-azaspirodecane structure (as in solasodine) and the solanidane type is derived by an indolizidine ring where tertiary nitrogen connects the 2 rings (as in solanidine). In these molecules, nitrogen can be bonded as a primary amino group (free or methylated), which forms simple steroidal bases, ring-closed to skeletal as secondary NH or in two rings as a tertiary N , which often regulates the chemical character of the molecule. Glycoalkaloids always contain double bonds and OH groups in various positions. Nearly 90 structurally unique steroidal alkaloids were reported from 350 Solanum species .
The ‘Two-Pin’ technique increases sanitation for multiple dose vial users. They draw with the first pin, and then shoot/inject into the body with a new one. This procedure prevents any residual contaminants that may have remained on the drawing pin from being transferred into the body via the injection site. It also makes injection less painful since the drawing needle is necessarily dulled during passage through the rubber stopper atop the vial. A dulled needle increases injection pain because it doesn’t pierce the body as cleanly as an unused one. The protocol below is followed by AAS users who draw from multiple dose vials, but steps 4 - 8 are routinely disregarded by those users who draw from ampoules (also called ampules) and sachets.