Dose reduction of steroids

Initial doses of mg/kg/day rounded to the nearest available patch strength (patches are available in 3 strengths delivering doses of approximately , , or mg/day over 7 days) were used in a small study including 7 pediatric patients (age range 5 to 12 years, weight range to kg). Patients weighing less than 25 kg were started on half a mg/day patch for 3 days to minimize adverse reactions. The mean dose of clonidine used in the study was +/- mg/day. Although patches in this study were changed every 7 days, other authors have suggested that pediatric patients may require patches be changed earlier (., every 5 days) due to variable absorption. Partial doses of patches may be administered by placing impermeable material (., adhesive bandage) on the skin under the patch proportionate to the desired dose reduction.

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). It is also known as NUROFEN, FENPAED.

  • Ibuprofen may be more effective when taken without food, with similar tolerability
  • Dose according to weight rather than age; ibuprofen is not recommended for infants less than 6 months
  • Ibuprofen is as or more efficacious than paracetamol (relatively small difference), and is equally safe
  • Appropriate therapeutic doses are remarkably free of adverse effects but long-term safety is unknown
When to treat Fever and Pain in my child?
  • Use paracetamol if the child appears distressed or unwell
  • Use ibuprofen (Nurofen, Fenpaed) if there is no response to paracetamol
  • Do not routinely use paracetamol and ibuprofen together at the same time, or alternately
  • Regardless of which analgesic/antipyretic, use only if necessary for the shortest period of time to control symptoms.
Paracetamol or Ibuprofen (Nurofen, Fenpaed)?
  • Paracetamol has analgesic (pain relief) and antipyretic(reduces fever) but no anti-inflammatory activity; it is less irritant to the stomach than Ibuprofen.
  • Ibuprofen (Nurofen, Fenpaed) has anti-inflammatory effects, and may be more effective than paracetamol in pain reduction in diseases in which inflammation is a major cause of tissue injury, such as juvenile rheumatic arthritis.
  • There is a relatively small difference in analgesic and antipyretic efficacy or adverse effects between paracetamol and intermittent oral dosing of ibuprofen.
  • For children without underlying medical conditions, or with underlying medical conditions that are not inflammatory in nature, beginning treatment with oral paracetamol is preferred because of its long track record of safety.
If the decision is made to use a non-steroidal anti-inflammatory drug (NSAID) for a child , ibuprofen is preferred because it is equally effective and has fewer adverse effects than other NSAIDs.

Dose reduction of steroids

dose reduction of steroids


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