Hydrocortisone steroid cream side effects

Over-use of any steroid cream, especially for long periods, on large areas of skin, can result in the body absorbing too much steroid. This may occasionally lead to a thinning and weakening of the skin. Some people with cracked or moist skin notice irritation when they apply the cream.
If you have a skin infection, this may spread or get worse. Red marks or lines may appear on the skin, the skin may become inflamed, you may get acne, or you may see a mild loss of pigment (colour) in the skin where the cream is used.
Skin thinning may occur where the skin rubs together or in the nappy area of young children.
Rarely local sensitivity may occur requiring discontinuation of treatment.
If you notice these or any other unusual effects, tell your doctor.

When activated macrophages start to secrete IL-1, which synergistically with CRH increases ACTH, [10] T-cells also secrete glucosteroid response modifying factor (GRMF), as well as IL-1; both increase the amount of cortisol required to inhibit almost all the immune cells. [11] Immune cells then assume their own regulation, but at a higher cortisol setpoint. The increase in cortisol in diarrheic calves is minimal over healthy calves, however, and falls over time. [58] The cells do not lose all their fight-or-flight override because of interleukin-1's synergism with CRH. Cortisol even has a negative feedback effect on interleukin-1 [10] —especially useful to treat diseases that force the hypothalamus to secrete too much CRH, such as those caused by endotoxic bacteria. The suppressor immune cells are not affected by GRMF, [11] so the immune cells' effective setpoint may be even higher than the setpoint for physiological processes. GRMF affects primarily the liver (rather than the kidneys) for some physiological processes. [59]

Hydrocortisone steroid cream side effects

hydrocortisone steroid cream side effects

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