Oral cutaneous t cell lymphoma

Cutaneous T cell lymphoma ( CTCL ) is a class of non-Hodgkin lymphoma , which is a type of cancer of the immune system . Unlike most non-Hodgkin lymphomas (which are generally B cell related), CTCL is caused by a mutation of T cells . The cancerous T cells in the body initially migrate to the skin , causing various lesions to appear. These lesions change shape as the disease progresses, typically beginning as what appears to be a rash which can be very itchy and eventually forming plaques and tumors before spreading to other parts of the body.

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Primary cutaneous CD4-positive small/medium T-cell lymphoma is a slow-growing lymphoma with a good prognosis (outlook). It usually appears as a single plaque or nodule on the face, neck or upper torso. Treatment is usually to remove the plaque or nodule surgically or attack it with radiotherapy. If the lymphoma is more widespread, your doctor may suggest drug treatment with either a chemotherapy drug called cyclophosphamide or an immunotherapy drug, interferon alpha. Localised disease of this type may be re-classified as a lymphoproliferative disorder rather than a cancerous condition in the future because of its slow-growing nature and good outlook.

Adult T-cell leukaemia /lymphoma (ATLL), is a serious blood disease in which there are large numbers of circulating atypical cells. It is caused by a retrovirus infection with human T-lymphotropic virus (HTLV I). The condition can be divided into acute and chronic types. Acute ATLL is characterised by skin lesions similar to those found in mycosis fungoides or Sézary syndrome , enlarged lymph glands, high levels of calcium in the blood and bone lesions. Prognosis is poor for this type with survival ranging from 2 weeks to more than 1 year. Chronic ATLL present with skin lesions only and have a longer clinical course and survival, however this may transform into an acute phase with an aggressive course.

Oral cutaneous t cell lymphoma

oral cutaneous t cell lymphoma

Adult T-cell leukaemia /lymphoma (ATLL), is a serious blood disease in which there are large numbers of circulating atypical cells. It is caused by a retrovirus infection with human T-lymphotropic virus (HTLV I). The condition can be divided into acute and chronic types. Acute ATLL is characterised by skin lesions similar to those found in mycosis fungoides or Sézary syndrome , enlarged lymph glands, high levels of calcium in the blood and bone lesions. Prognosis is poor for this type with survival ranging from 2 weeks to more than 1 year. Chronic ATLL present with skin lesions only and have a longer clinical course and survival, however this may transform into an acute phase with an aggressive course.

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