Single agent corticosteroid

Forty three eligible trials (48 comparisons) were identified. These included 9742 women, 55% of whom were receiving first-line treatment for metastatic disease. For overall survival there was a statistically significant difference in favour of the combination regimens with no heterogeneity (HR , 95% CI -, p<). Results were very similar when trials of first-line treatment were analysed, and for analyses where the single agent was also included in the combination regimen . Combination regimens showed a statistically significant advantage for survival over single agent taxane (HR ; 95% CI -, p<), but not anthracycline (HR -, p=).

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As nerve agents, the Novichok agents belong to the class of organophosphate acetylcholinesterase inhibitors . These chemical compounds inhibit the enzyme acetylcholinesterase , preventing the normal breakdown of the neurotransmitter acetylcholine . Acetylcholine concentrations then increase at neuromuscular junctions to cause involuntary contraction of all skeletal muscles ( cholinergic crisis ). This then leads to respiratory and cardiac arrest (as the victim's heart and diaphragm muscles no longer function normally) and finally death from heart failure or suffocation as copious fluid secretions fill the victim's lungs. [60]

Single agent corticosteroid

single agent corticosteroid

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