Forty three eligible trials (48 comparisons) were identified. These included 9742 women, 55% of whom were receiving first-line treatment for metastatic disease. For overall survival there was a statistically significant difference in favour of the combination regimens with no heterogeneity (HR , 95% CI -, p<). Results were very similar when trials of first-line treatment were analysed, and for analyses where the single agent was also included in the combination regimen . Combination regimens showed a statistically significant advantage for survival over single agent taxane (HR ; 95% CI -, p<), but not anthracycline (HR -, p=).
Our website gives you internet access to all listed properties for sale in the Puget Sound region, including Arlington, Everett, Marysville, Bothell, Bellevue, Woodinville and Seattle.
The real estate agents at Preview Properties can help you find and buy single family homes, condos, income properties and commercial buildings for sale in the Puget Sound area. Use this website to search all properties listed in the Seattle / Puget Sound WA area.
We can help you choose the right home or property for your needs and will guide you toward making an informed real estate decision. We pride ourselves in being able to give all our clients important local information based on years of living and enjoying everything the area has to offer.
Short Sale Help
If you need to sell your home and the current value is less than amount you owe on the mortgage, a short sale may be the right choice for you. A Preview Properties agent can help guide you through the Short Sale process. You may even be eligible for $3,000 - $30,000 for relocation assistance from your lender when your short sale closes escrow.
If you are a seller, we can help price and put your Everett, Marysville, Bothell, Bellevue and Seattle property on the market for a quick sale. If you'd like to find out the value of your home or property, go to our " Your Home Value " page and submit a CMA request. We will research the value of your home or property for you. This is a free service provided by Preview Properties, Inc.
This site is designed to help you make the important decisions needed to purchase or sell real estate, homes, or property. Bookmark it for future reference and feel free to call or e-mail us for all of your real estate needs.
As nerve agents, the Novichok agents belong to the class of organophosphate acetylcholinesterase inhibitors . These chemical compounds inhibit the enzyme acetylcholinesterase , preventing the normal breakdown of the neurotransmitter acetylcholine . Acetylcholine concentrations then increase at neuromuscular junctions to cause involuntary contraction of all skeletal muscles ( cholinergic crisis ). This then leads to respiratory and cardiac arrest (as the victim's heart and diaphragm muscles no longer function normally) and finally death from heart failure or suffocation as copious fluid secretions fill the victim's lungs.