Neil S. Sachanandani, ., and colleagues at the Washington University School of Medicine, St. Louis, assessed the effects of budesonide on adrenal function in nine patients between 2005 and 2006. Participants were instructed to use a nasal wash composed of milligrams of budesonide and 5 milliliters of saline in each nostril once daily for 30 days. At clinic visits before and after the treatment period, participants completed a questionnaire assessing their rhinosinusitis symptoms and related quality of life. Their cortisol levels were measured after injection with cosyntropin, a compound that stimulates the release of cortisol by the adrenal glands—a standard method of testing adrenal function.
Steroid nasal spays -- this is an awesome alternative for people and dogs with allergies. Since they are topical in the nose -- they have no systemic effect -- only local effect or reduction of inflammation in the nasal passages. Used widely in human medicine, there are some references to use in dogs. May be less effective if dog has a very long nose -- more effective if shorter nosed. Applied once daily in most cases just like a human nasal spray. Takes 2 weeks to see full effect. Generenic fluticasone nasal spray is available. These are prescription -- and after using and calming the nasal passages for 2 weeks -- you may be able to drop back to use in rotation of nostril used in -- or use every other day.,