Steroidal cream for phimosis

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NSAIDs have anti-inflammatory (reduce inflammation), analgesic (relieve pain) and antipyretic (lower temperature) effects. Although different NSAIDs have different structures, they all work by blocking cyclooxygenase (COX) enzymes. There are two main types of COX enzymes: COX-1 and COX-2. Both types produce prostaglandins; however, the main function of COX-1 enzymes is to produce baseline levels of prostaglandins that activate platelets and protect the lining of the gastrointestinal tract, whereas COX-2 enzymes are responsible for releasing prostaglandins after infection or injury. Prostaglandins have a number of different effects, one of which is to regulate inflammation. Most NSAIDs inhibit both enzymes, although a few are available that mainly inhibit COX-2. The pain-relieving and anti-inflammatory effects of NSAIDs are mainly due to inhibition of COX-2, and their unwanted side effects are largely due to inhibition of COX-1.

As a result of this, expert panels are reluctant to endorse topical steroids being sold over-the-counter. They fear that parents wouldn't understand the risks when buying the drugs to use at home. While in most cases the effects of topical steroids on the HPA axis means only the child is at minimal risk, if they undergo a stressful physiologic (rather than psychologic) event such as trauma, surgery, or serious infection, they might have life-threatening complications. The effects on the HPA axis are reversible and usually return to normal within weeks.

Steroidal cream for phimosis

steroidal cream for phimosis

As a result of this, expert panels are reluctant to endorse topical steroids being sold over-the-counter. They fear that parents wouldn't understand the risks when buying the drugs to use at home. While in most cases the effects of topical steroids on the HPA axis means only the child is at minimal risk, if they undergo a stressful physiologic (rather than psychologic) event such as trauma, surgery, or serious infection, they might have life-threatening complications. The effects on the HPA axis are reversible and usually return to normal within weeks.

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